In high-fat, streptozotocin-induced type 2 diabetic Wistar rats, the effect of a phenolic and alkaloid extract from Senna Occidentalis leaves on the heart's oxidative status was studied.

Abstract

The purpose of this study was to investigate the impact of Senna occidentalis leaf extracts (alkaloid and phenolic) on the oxidative state of the heart in Streptozotocin-induced Wistar rats that were given a high-fat diet. The rats were inoculated intraperitoneally with 35 mg/kg of streptozotocin to induce type 2 diabetes. Research Tools and Procedures: Group 1 served as the control group and included seven rats out of a total of 43 rats that were randomly assigned to one of seven groups of six. The other groups were as follows: Diabetes rats that were not treated, rats that were treated with metformin, rats that were treated with phenolic extract, rats that were treated with alkaloids extract, rats that were treated with high doses of phenolic extract, and rats that were treated with high doses of alkaloids extract. Antioxidant status was determined by measuring the activity levels of many biochemical variables, including catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione, and malondialdehyde. The results of this investigation suggested that S. occidentalis phenolic and alkaloid extracts might be useful in the treatment of type 2 diabetes due to their antioxidant characteristics.