For the treatment of dry eyes caused by the suppression of the JAK2/STAT3 pathway, a combination of Runmu fengye tang preparation and hydroxysugar glycolic acid eye drops is recommended.

Abstract

The goal of this study is to identify therapeutic approaches that successfully address dry eye in clinical settings.
Methods: Eye drops containing glycerol, dextran 70, and Runmu Fengliang tang (RMFS) were given to rabbits in a
model of scopolamine-induced dry eye (HGA). Dry eye symptoms and lacrimal gland damage were assessed using
Schirmer's I test (SIt), break-up time (BUT), and histopathologic exams (H&E). Apoptotic cell count and Th17/Treg
percentages were determined by flow cytometry, and JAK2/STAT3 pathway protein expression was assessed by
Western blot test. Findings: In the rabbit scopolamine-induced dry eye model, the combination of RMFS with HGA
considerably enhanced tear production (p < 0.001), decreased tear break-up time (p < 0.001), restored ocular
surface damage, and decreased apoptosis (p < 0.05) as compared to the group that received just one injection of the
medication. Furthermore, it suppressed the JAK2/SATA3 pathway and controlled the balance of cytokines
associated to Th17 and Tregs. In conclusion, scopolamine-induced dry eye symptoms are alleviated in rabbit models
when RMFS and HGA are administered together, suggesting that this medication may be useful in the treatment of
dry eye illness. Collecting clinical data to examine the combination's effectiveness and safety should be the focus of
future investigations. Topics covered include: hypromellose 2910, runmu fengliang tang, glycerol eye drops, the
th17/treg and JAK2/SATA3 pathways, and dry eye syndrome.